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Design of antibacterial substituted hydroxyapatite coatings for biomedical applications using the electrostatic spray deposition technique

Mis à jour le 12 juillet 2019
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This is a 6-months internship mainly localised in Grenoble (St Martin d’Hères Campus), the biological assessments will be conducted in Lyon.

Summary
Replacement of missing or diseased hard tissues has become a common procedure in medicine and dentistry. In this field, coatings are frequently applied onto the surface of metallic implants, such as titanium and titanium alloys in order to improve their biological performance. Calcium phosphate (CaP) family, has been chosen as a synthetic material for this purpose due to its bioactivity and osteoconductivity properties [1]. In addition, one of the major constituents of bone is a CaP whose structure closely resembles hydroxyapatite (HAp), Ca10(PO4)6(OH)2. This biological apatite is poorly crystallized, non-stoichiometric with multiple cationic and anionic substitutions [2].
Although using HAp improves the biological response to the implant there are still several limitations to use pure HAp as a coating material, including a lack of antibacterial activity and of long term stability, that may and cause implant failures. There is a significant need for solutions that can fight infection locally and over time. An approach could be the use of multifunctional biomaterials associating inherent therapeutic and anti-microbial abilities. In recent years, the incorporation of inorganic antibacterial cations into HAp structure, has been proposed [3]. This strategy may represent a smart tool to improve clinical outcomes while providing locally-targeted inhibition of infectious processes.
In this respect, this project aims to develop and characterize doped hydroxyapatite coatings of optimized architectures, compositions, and structures by using the Electrostatic Spray Deposition technique (ESD) on biomedical grade titanium substrate.
The Master student will work in two laboratories, LEPMI (Grenoble INP) and MATEIS (INSA Lyon) through an ANR project related to DEFI 4 (Life, Health and Welfare). He or she will have to closely collaborate with a large team, and especially with a Ph.D. student currently working on the project. This is a 6-months internship mainly localised in Grenoble (St Martin d’Hères Campus), the biological assessments will be conducted in Lyon.
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mise à jour le 12 juillet 2019

Contacts

Supervisor(s) : Elisabeth Djurado; Verónica Müller
Laboratory : LEPMI Team/Group : MIEL
Contacts - E-mail : elisabeth.djurado@lepmi.grenoble-inp.fr Tel : +33 (0)476826684 Web-page : http://lepmi.grenoble-inp.fr/

Documents à télécharger

Univ. Grenoble Alpes